The following is the Studies have found that depression in youth is more likely to lead to dementia in old age From UCSF recommended by recordtrend.com. And this article belongs to the classification: Life data.
Pressure from school, work, social, family and other aspects may make many young people unknowingly produce depressive symptoms. According to a new study, scientists remind young people not to ignore their mental health because it may have a far-reaching impact on the rest of their life. Researchers at the University of California, San Francisco (UCSF) found that depression in youth may accelerate cognitive decline and increase the risk of Alzheimer’s disease in the future. The study was recently published in the professional academic journal Journal of Alzheimer’s disease.
Published in Journal Of Alzheimer’s disease
The researchers summarized the health data of more than 15000 adults from four cohorts. According to the scale tool for screening depression, the researchers used innovative statistical methods to estimate the average development trajectory of depressive symptoms in the three life stages of youth (20 ~ 49 years old), middle age (50 ~ 60 years old) and old age (70 ~ 89 years old). Then, using the prediction trajectory, combined with the cognitive ability scores of more than 6000 elderly participants, the researchers analyzed the relationship between the development trajectory of depressive symptoms and the decline of brain cognitive function.
In general, the more severe the depression, the lower the cognitive ability and the faster the cognitive decline. But they found that among those who had moderate to severe depressive symptoms in their youth, the probability of cognitive impairment in old age increased by 73%, which was higher than those who suffered from depression in old age.
“People with moderate or high depressive symptoms in youth have cognitive decline after ten years,” the researchers noted.
Why depression increases the risk of dementia? Dr. Willa brenowitz, the first author of the research paper, analyzed that there may be several mechanisms, such as the brain damage caused by related hormones. “One mechanism is that the brain’s system responsible for stress response is hyperactive, which increases the production of stress hormone glucocorticoid, resulting in damage to the hippocampus, which is an indispensable part of forming and storing memory,” she said.
Professor Kristine Yaffe, the corresponding author of the study, added that in the process of data statistics, they found that 13% of young people, 26% of middle-aged people and about 1 / 3 of the elderly have moderate to severe depressive symptoms. Therefore, it is very important to recognize the role of depression in cognitive decline.
“Whether depression can be identified and treated in youth to improve the consequences of brain aging, such as preventing Alzheimer’s disease or other dementia, is a very key issue,” she said. The researchers believe that if it can be prevented as soon as possible, it will change life.
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