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The following is the Studies have found that intestinal bacterial strains may have metabolic and mental health benefits From Cork University recommended by recordtrend.com. And this article belongs to the classification: Life data.
A powerful new study investigates the prospective anti obesity effect of a specific intestinal bacterial strain. From preclinical animal studies to placebo-controlled human trials, powerful transformation studies have shown that a new bacterial strain may confer several metabolic benefits.
The new study investigated the effects of a very specific bacterial strain, Bifidobacterium longum apc1472. Previous studies have shown that this particular bacterial strain seems to help regulate ghrelin levels, a hormone known to regulate appetite and fat metabolism.
The study, led by scientists at the University of cork, first examined the effects of B. longum apc1472 on a preclinical mouse model of diet induced obesity. Probiotics not only reduced fat deposition and induced weight loss in obese mice, but also improved glucose tolerance and reduced fasting cortisol level.
Of course, what works in mice doesn’t necessarily work in humans, so the researchers then did what’s called translational research. The researchers recruited more than 100 healthy but obese human subjects and randomly divided them into placebo or treatment groups. The active group received B. longum apc1472 supplement for 12 weeks.
Human trials have shown that many of the beneficial metabolic effects seen in animal studies do translate into human subjects. Bacterial intervention reduced the level of fasting blood glucose and normalized the level of active ghrelin. Subjects in the active treatment group also showed decreased levels of stress hormone cortisol, which confirmed the findings in preclinical animal studies.
Importantly, the study noted that no changes in overall body weight or BMI were found in human trials. As a result, 12 weeks of probiotic supplements did not have any direct effect on weight, suggesting that this particular strain of bacteria is unlikely to be the only panacea for obesity. The researchers speculate that there are many factors that can explain the discordance of weight loss between animal and human studies.
“This difference may be explained by the fact that most of the human intervention cohort is non-diabetic patients, and HFD (high-fat diet) induced impaired glucose tolerance in obese mice, suggesting that host glucose metabolism may be a major factor contributing to weight loss in obese mice,” the researchers wrote in the study. “It must also be noted that preclinical studies take a longer time to treat and therefore, in human intervention studies, longer treatment time or higher treatment dose may lead to more significant differences and larger effect scale.”
Nevertheless, the metabolic effects of probiotic interventions seen in the human cohort confirm potential therapeutic uses. Harriet schellekens, CO senior author of the study, said the study provided a promising signal that this particular bacterial strain might be useful for people with diabetes or prediabetes.
“This study is the first to demonstrate the transformation of B. longum apc1472 from an initial laboratory study through preclinical studies to human intervention studies,” schellekens said. “This study suggests that B. longum apc1472 has the potential to be developed as a valuable probiotic supplement to reduce blood sugar, which is very important for the development of diseases such as type 2 diabetes.”
Timothy Dinan, one of the project’s clinical researchers, also believes that this bacterial strain may play an important role in regulating cortisol levels. So the relationship between the probiotics and the stress in obesity is likely to be well documented.
“The results of translational studies are reliable, and the regulation of cortisol arousal response deserves further study of this B. longum apc1472 and its potential use as a psychobiological agent to improve mental health,” Dinan said.
The new study is published in the Journal ebiomedicine.
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