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The study found that polysaccharide diet is not conducive to children’s brain development From University of Georgia & University of Southern California

The following is the The study found that polysaccharide diet is not conducive to children’s brain development From University of Georgia & University of Southern California recommended by And this article belongs to the classification: Life data.

On the shelves of grocery stores, candy wrapped in various kinds of “coats” seems to “scream” at customers, stimulating people’s desire to buy, especially those products for children. Children are the biggest consumers of carbohydrate additives. However, high sugar diet is associated with obesity, heart disease, and even memory impairment. However, little is known about the effects of high glucose intake in childhood on brain development, especially the hippocampus, which is crucial for learning and memory.

Recently, a new study led by researchers from the University of Georgia and the University of Southern California shows that drinking sugary drinks every day during adolescence can damage the learning and memory abilities of adults through rodent models. This study further suggests that the change of intestinal bacteria may be the key to glucose induced memory impairment.

In a recent study published in translational psychiatry, the authors also found that similar memory deficits could be observed even in the intestines of animals that had never ingested sugar if a bacterium called parabacteroides was enriched in the experiment.

“Sugar in early life increases the level of parabacteroides, and the higher the level of parabacteroides, the worse the animals perform in the task.” “We found that bacteria alone can damage memory as much as sugar, but it can also damage other types of memory,” said Emily noble, lead author and assistant professor at the University of Georgia School of family and Consumer Sciences

The dietary guidelines for Americans, jointly published by the U.S. Department of agriculture and the U.S. Department of health and human services (HHS), recommends that the daily intake of added sugar should be controlled below 10% of calories.

However, according to the U.S. Centers for Disease Control and prevention, Americans between the ages of 9 and 18 eat more sugary diets than recommended, and most of their calories come from sugary beverages.

Given the role of the hippocampus in various cognitive functions and the fact that it is still developing in late adolescence, researchers are trying to learn more about its vulnerability to a high sugar diet through the gut microbiota.

They fed the pups a normal diet and an 11% sugar solution, which was comparable to the sugar drinks on the market.

The mice were then asked to perform a hippocampus dependent memory task designed to measure episodic contextual memory, or the context in which they had seen familiar objects before.

“We found that the ability of early sugar fed mice to identify new things in a particular environment was impaired, while the ability of non sugar fed mice to perform this task was impaired.” Noble said.

The second memory task tested basic recognition memory, which is a memory function independent of the hippocampus and involves the ability of animals to recognize what they saw before.

In this task, sugar had no effect on the recognition and memory of the animals.

“Sugar intake early in life seems to selectively impair learning and memory in their hippocampus,” noble said

Further analysis showed that high glucose intake increased the level of parabacteroides in the intestinal microbiota, and there were more than 100 trillion microorganisms in the intestinal microbiota, which played an important role in human health and disease.

To better identify the mechanism by which the bacteria affect memory and learning, the researchers increased the level of parabacteroides in the microbiome of mice that had never ingested sugar. These animals showed impairment in both hippocampus dependent and hippocampus independent memory tasks.

“The bacteria itself causes some cognitive deficits. Now the question is, how do these bacterial populations in the gut alter brain development? ” Determining how gut bacteria affect brain development can help tell people what internal environment the brain needs to grow healthily, noble said. Therefore, future research needs to better identify the specific pathway of visceral brain signal operation.

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