Studies have found that living alone for too long is prone to lack of sleep and overeating From Rockefeller University
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It’s cool to live alone for a while, but will it really be cool to fly in the sky after living alone for a long time? Not necessarily. Recently, biologists from the Rockefeller University found that living alone for a long time can lead to overeating and lack of sleep! In addition, they also found neurons suspected of “loneliness switch” through experiments.
It can be activated manually and create “loneliness” artificially!
Lonely fruit flies also eat more and sleep less
The experiment took place on the fruit fly, the biologist’s ancestral friend.
Like humans, fruit flies are social animals, sleeping an average of 16 hours a day.
Wanhe Li in the team designed a group control experiment to verify that fruit flies have similar behavior to humans.
She raised 1, 2, 5, 25 and 100 fruit flies in the following containers from left to right:
The fruit fly on the far left, which enjoys a single room, is a gregarious creature in a state of social isolation.
After 7 days, the proportion of Drosophila melanogaster “living alone” was significantly lower than that of Drosophila melanogaster living in groups:
△ red ISO is isolated fruit fly
The same is true for total sleep time:
This is the source of the “lack of sleep” behavior.
When comparing Drosophila flies living in groups and living alone for one day, Drosophila flies living alone for seven days always have more obvious differences in gene expression:
Specifically, there are differences in the expression of metabolic genes.
Under the action of genes, even if organisms continuously obtain food, the brain will still be in a state of “hunger”.
If you are hungry after eating, you will gain weight.
So, what kind of pathological mechanism does this chronic social isolation affect the body’s sleep and metabolism?
“Autism switch” – P2 neuron
Loneliness can have pathological consequences, which may be related to the changes of a small group of neurons.
Team leader Michael W. Young said.
In the experiment, the team observed that P2 neurons in the brain were involved in changes in sleep and eating behavior:
When inhibiting the activity of these neurons, even a single fly can be calm and have no symptoms of “eating more and sleeping less”.
However, if this “switch” is activated manually, even if it is only separated from the large army for one day, the Drosophila will feel double lonely, as if it had lived alone for a week
This led Dr. Wanhe Li to guess the function of P2 neurons:
It (P2 neuron) is like a timer that continuously calculates the length of social isolation or the degree of loneliness.
Of course, this is not the decisive switch to control loneliness.
——As long as fruit flies mix with their partners every day, even if these P2 neurons are activated, fruit flies will not have those lonely symptoms.
It’s like social behavior can constantly clear the “lonely timer”.
So can this specific mechanism between chronic social isolation, metabolism and sleep also be extended to humans?
Michael W. Young said:
Although this study is difficult to confirm that humans who live alone for a long time eat more and sleep less also come from the same biological mechanism.
However, how long-term disengagement affects gene expression, neural activity and behavior of Drosophila has provided a powerful biological model.
In the first mock exam of animal response to loneliness, researchers can continue to look for the relationship between laboratory animal and human body.
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