“Hot head” has scientific basis! The highest brain temperature is nearly 41 ℃, and women’s brain is hotter than men’s

The following is the “Hot head” has scientific basis! The highest brain temperature is nearly 41 ℃, and women’s brain is hotter than men’s recommended by recordtrend.com. And this article belongs to the classification: Life data.

Abnormal temperature throughout the body has been regarded as a symptom of disease for more than 2000 years. The measurement of trunk temperature is simple, and abnormal temperature often implies the information of disease diagnosis. In contrast, brain temperature can be measured directly with the help of invasive means, so there are few studies on it, and its clinical significance is not clear.

Recently, Dr. Nina rzechorzek and his team from the laboratory of the medical research committee of molecular biology at the University of Cambridge published their latest research papers in the famous Neuroscience journal Brain. This study used magnetic resonance spectroscopy (MRS) brain scanning technology to measure brain temperature and drew the first 4D map of brain temperature in healthy humans, showing the significance of brain temperature changes with brain region, age, gender and time of day. In addition, the research team also analyzed the data of patients with traumatic brain injury, indicating that the daily rhythm of brain temperature is closely related to the survival of patients. These findings are helpful to improve the understanding of brain injury, treatment and prognosis.

In the past, direct measurement of brain temperature required invasive means, so such data can only be obtained from brain injury patients in the intensive care unit. In this study, Mrs brain scanning technology was used to enable researchers to noninvasively measure the brain temperature of healthy people.

In order to study the brains of healthy people, researchers recruited 40 volunteers aged between 20 and 40 to conduct brain scans in the morning, afternoon and evening of the day.

The data showed that in healthy subjects, the average temperature of the brain was 38.5 ℃, which was more than 2 ℃ higher than the temperature measured under the tongue. The study also found that brain temperature changes depend on the time of day, brain region, gender, menstrual cycle and age.

The surface temperature of the brain is generally low, but the temperature of the deep structure of the brain is often higher than 40 ℃, and the highest brain temperature observed in all subjects is 40.9 ℃. The average brain temperature of women is about 0.4 ℃ higher than that of men. The researchers speculate that this gender difference may be caused by the menstrual cycle, because most women take brain temperature measurement after ovulation, and their brain temperature is about 0.4 ℃ higher than the scanning temperature before ovulation.

The results also showed that in the 20-year study, the brain temperature of participants increased with age, and the temperature increase in the deep brain region was the most significant, with an average increase of 0.6 ℃. The cooling capacity of the brain may decline with age, so it is necessary to further study whether this change is related to the occurrence and development of age-related brain diseases.

Brain temperature of healthy people over time in a day (source: Figure 4)

For the temperature data of healthy human brain, Dr. John O’Neill, the corresponding author of this article, commented: “for me, the most surprising discovery in our study is that healthy human brain can reach the temperature that other parts of the body are diagnosed with fever. Such high temperature has been measured in patients with brain injury in the past, but it has always been considered to be caused by brain injury.” He also said, “we found that brain temperature decreases before going to bed at night and increases during the day. We have good reasons to believe that this daily change is related to the long-term health of the brain – this is where we hope to conduct research next.”

In order to further explore the clinical significance of these data, researchers collected and analyzed brain temperature data of 114 patients with moderate to severe traumatic brain injury. The results showed that the average brain temperature of these patients was 38.5 ℃, but the range of change was larger, ranging from 32.6 ℃ to 42.3 ℃. In 100 patients, only a quarter of them have daily periodic changes in brain temperature and daily rhythm of brain temperature.

Researchers focused on the prognosis of survival in intensive care. They found that a single brain temperature measurement has limited effect on survival prediction, but daily brain temperature changes are closely related to survival – in fact, the mortality of patients with traumatic brain injury with brain temperature daily rhythm in intensive care is only 4%, while the mortality of patients without such rhythm is 27%.

Nevertheless, the researchers stressed that this association should be treated with caution, and the conclusions need to be verified by larger studies. Moreover, the relationship between brain temperature and survival is only statistically significant, which does not mean that the daily rhythm of brain temperature can directly increase the survival rate of patients. However, the association found in this study may suggest that monitoring the daily brain temperature cycle of patients with traumatic brain injury may be a potential survival prediction tool.

For this work, Dr. Nina rzechorzek, the first author, said: “We have established ‘heatwave’ – a 4D temperature map of the brain. As an important reference data resource, this map can be compared with the data of patients, so as to deepen our understanding of the working mechanism of the brain. The daily rhythm of brain temperature is closely related to the survival rate of patients after brain injury, indicating that 24-hour brain temperature monitoring has great clinical value. Our work also opens a door for future research, whether it can be It is worth further exploration to regard the disorder of daily rhythm of brain temperature as an early biomarker of several chronic brain diseases such as dementia. “

reference material:

1.Rzechorzek NM, Thrippleton MJ, Chappell FM, et al. A daily temperature rhythm in the human brain predicts survival after brain injury [published online ahead of print, 2022 Jun 13]. Brain. 2022;awab466. doi:10.1093/brain/awab466

2.http://www.sci-news.com/othersciences/physiology/human-brain-temperature-10898.html

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