22 years of Chinese research shows that eating garlic for a long time reduces the risk of death from gastric cancer by 34% From BMJ

The following is the 22 years of Chinese research shows that eating garlic for a long time reduces the risk of death from gastric cancer by 34% From BMJ recommended by recordtrend.com. And this article belongs to the classification: Life data.

“If you eat noodles without garlic, you will lose half the flavor.”. Sichuan’s garlic paste white meat, Hainan’s garlic vermicelli shrimp, Shaanxi’s garlic dip noodles… Garlic has occupied an important position in “China on the tip of the tongue” and achieved countless Chinese delicacies.

It is no exaggeration to say that the origin of Chinese people and garlic has a history of thousands of years. In Er Ya Yi, written by Luo Yuan in Song Dynasty, there is a saying that “Hu people use garlic to paint their bodies, love their fragrance, and protect their cold” (the perfume with garlic flavor is really unique). Lishizhen, a medical scientist in Ming Dynasty, summed up that the efficacy of garlic is “to pass through the five internal organs, reach all orifices, remove cold and dampness, ward off evil, reduce swelling and pain, and turn meat into food”.

People who have eaten garlic have this experience. Cover your mouth when talking to others after dinner. It is the unique pungent flavor of garlic that polarizes people’s attitude towards it. So from the perspective of modern medicine, does this garlic, which people love and hate, have any health benefits?

A 22-year randomized controlled trial (RCT) conducted by you Weicheng, Dean of the school of Clinical Oncology of Peking University, evaluated the effects of Helicobacter pylori treatment, vitamin supplement and garlic supplement on the prevention of gastric cancer. The results showed that the continuous intake of garlic supplement for 7 years was related to the reduction of the risk of death from gastric cancer, which was similar to the two-week treatment of Helicobacter pylori and the intake of vitamin supplement for 7 years, But it has nothing to do with the decrease of incidence rate of gastric cancer. The research paper was published in BMJ.

Linqu County, Shandong Province is one of the regions with the highest mortality rate of gastric cancer in the world. From 1980 to 1982, the mortality rate of gastric cancer was 55 / 100000 men and 19 / 100000 women (after age adjustment). In 1995, researchers recruited volunteers in Linqu County. After inclusion criteria screening, a total of 3365 volunteers from areas with high incidence of gastric cancer were finally included as the subjects of RCT.

The age of 3365 subjects ranged from 35 to 64 years. Among them, 2258 subjects with seropositive Helicobacter pylori antibody were randomly assigned to three intervention measures or placebo group, which were Helicobacter pylori treatment group, vitamin supplement group and garlic supplement group; 1107 H. pylori negative subjects were also randomly assigned to vitamin supplement group, garlic supplement group or placebo group.

The situation of each group is as follows:

I made it on my own.

After 22.3 years of follow-up from 1995 to 2017, 151 gastric cancer patients and 94 gastric cancer deaths occurred in all 3365 subjects. Among them, 79% of gastric cancer patients and 81% of gastric cancer deaths came from people who were positive for Helicobacter pylori at baseline.

Helicobacter pylori treatment and vitamin supplements can significantly reduce the risk of gastric cancer. After multivariable adjustment, the risk of gastric cancer was 52% (P < 0.001) lower in participants treated with H. pylori than in the control group, and 36% (P = 0.02) lower in participants taking vitamin supplements than in the control group. In terms of the proportion of gastric cancer, participants taking garlic supplements were slightly less than those in the control group, but the difference was not significant.

From the perspective of gastric cancer mortality, the three intervention measures are their protective factors, which are statistically significant. Helicobacter pylori treatment reduced gastric cancer mortality by 38%, vitamin supplement intake by 52% and garlic supplement intake by 34%. However, no association was found between the above three interventions and deaths from other cancers or cardiovascular diseases.

Further Kaplan Meier curves showed that the effect of Helicobacter pylori treatment and vitamin supplement intake on gastric cancer mortality became more obvious after about 8 years, while garlic supplement intake became more obvious after about 12 years.

However, the researchers also said that comparing the therapeutic effects of the three intervention methods in reducing the risk of gastric cancer incidence and death, it was found that there was no significant heterogeneity among the three methods. In other words, the effect of garlic supplements may be slow, but the effect will be gradually obvious and can last for 22 years!

In conclusion, this study found that 2 weeks of Helicobacter pylori treatment and continuous intake of vitamin supplements for 7 years can significantly reduce the risk of gastric cancer incidence and death, and the protective effect exists for a long time. Garlic supplementation did not significantly reduce the risk of gastric cancer, but it could significantly reduce the risk of gastric cancer death.

In addition, the new study published by professor you Weicheng’s team on JAMA network open one year later comprehensively analyzed the gastric cancer of the subjects after incorporating the lifestyle. The results showed that among people who never drank alcohol, the protective effect of garlic supplement was more significant, and the risk of death from gastric cancer decreased by 67% compared with the control group!

At the end of the paper, the author of this study said that at present, Helicobacter pylori treatment is a more effective method to prevent gastric cancer, but it can not completely eliminate the occurrence of gastric cancer, and may also lead to drug resistance. Vitamin and garlic supplements have potential value in reducing the risk of morbidity and mortality of gastric cancer. Although the effect is slow and may take several years to have an impact, it is also a low-cost, safe and effective measure in the long run.

Of course, this study also leaves some problems to be solved. For example, can eating garlic alone have an effect similar to garlic capsule? How much garlic can you eat a day? How do I eat this garlic? Wait, wait, wait. More research is needed to answer.

It’s really a wonderful “garlic”!

reference material

[1]Li W, Zhang J, Ma J, Li Z, Zhang L, Zhang Y et al. Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized interventiontrial BMJ 2019; 366 :l5016 doi:10.1136/bmj.l5016

[2]Guo Y, Li Z, Zhang J, et al. Association Between Lifestyle Factors, Vitamin and Garlic Supplementation, and Gastric Cancer Outcomes: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2020;3(6):e206628. doi:10.1001/jamanetworkopen.2020.6628

Author swagpp

Editor | swagpp

Source ｜ mace medicine

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