“Good” bacteria in the gut play a key role in brain health?

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Things that are good for intestinal health may also be good for brain health. Recently, in a research report entitled “association of the gut microbiota with cognitive function in midlife” published in the international journal JAMA network open, scientists from the University of North Carolina and other institutions found through research that individuals with stronger flora balance in the intestine may perform better in standard thinking skills tests, including attention Flexibility, self-control and memory. To be exact, researchers do not know how bacterial communities in the gut affect brain health, but the researchers have put forward some theories.

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Researcher Katie Meyer said that through the study of animal models, it has been found that intestinal flora may be involved in systemic inflammation, which is a risk factor for brain pathology. As we all know, the Mediterranean diet is rich in fruits and vegetables, whole grains, nuts, seeds and lean protein, and contains low levels of processed foods. In addition, regular physical exercise may be beneficial to the brain health of people. These health behaviors are related to the characteristics of intestinal flora. The protective effects of diet and exercise may be different, which are played by intestinal flora.

The intestinal microbiome consists of trillions of microorganisms and their genetic material. In this study, the researchers studied nearly 600 participants with an average age of 55 and analyzed the characteristics of the flora colonized in their intestines. Instead of sequencing all the genetic material, the researchers analyzed the genes that can identify the general bacterial community without going into specific details. Individuals with intestinal flora diversity tend to perform better in the six standard thinking skills and memory tests. A variety of specific types of bacteria seem to affect the performance of psychological tests, including barnesiella, fcs020 genus of spirillidae, sartrella, etc. But the researchers say they must study and understand the mechanism and why.

The researchers said that we know that the characteristics of the whole microbial population are related to many factors, but we are not sure which colony members or characteristics may be related. This study reveals the key role of intestinal flora in body health and disease occurrence; Professor John bienenstock said that generally speaking, increasing bacterial diversity is beneficial to the body’s intestinal health, while the decline of diversity level may not be beneficial to the body’s health. This view may apply to a range of health conditions, including brain health; In this study, researchers included a large group of people from different races and communities, but more in-depth research is needed later to understand its impact.

The researchers believe that this study may help to understand the role of intestinal brain axis in the body’s mental function and functional abnormalities. They also need more human data to further investigate the important relationship between body cognition and intestinal microbiome; The link between the brain and the gut is well known, but the link may not prove a causal link. So researchers need to study whether manipulating the microbiome can have any therapeutic value for brain health, but this may be easier said than done.

coming https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788843

Some people will take probiotic supplements to help reset the balance between beneficial and harmful flora in their intestines, so as to help improve their physical health, but this does not mean only a flora, but must call for the integration of bacterial communities; And this starts with adding more plant-based fiber to the diet, which can feed beneficial bacteria and increase the diversity of the body’s intestinal microbiome.

To sum up, in this cross-sectional study, based on β The microbial community composition of diversity may be related to all cognitive improvement measures in multivariable adjustment analysis; Relevant research data may suggest that intestinal flora may be related to the body’s cognitive aging, but researchers must confirm this association in a larger sample and further study to determine the relevant pathway.

Original source:

Katie Meyer, ScD1,2; Anju Lulla, PhD1; Kunal Debroy, BS3; et al Association of the Gut Microbiota With Cognitive Function in Midlife, JAMA Network Open (2022). DOI: 10.1001/jamanetworkopen.2021.43941

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