In depth Research Report on collagen industry in 2021 From Huachuang securities

The following is the In depth Research Report on collagen industry in 2021 From Huachuang securities recommended by recordtrend.com. And this article belongs to the classification: Brokerage Report, Life data.

Collagen triple helix structure has biological activity, complex formation process and high requirements for industrialized preparation. Collagen is widely distributed in human tissues. An adult human body contains about 3kg collagen. The unique triple helix structure of collagen determines its biological activity. It undertakes the functions of cell scaffold, promoting cell adhesion, promoting cell repair and so on. However, due to the complex biological reaction from amino acid → polypeptide chain → procollagen (triple helix monomer) → fibril → collagen fiber, it is relatively difficult to industrialized preparation while maintaining high mass production and taking into account the requirements of biological activity, high purity and low endotoxin. At present, large-scale production is still mainly carried out by animal source extraction in the world, and China’s collagen recombination technology is at the international leading level.

Collagen fillers were used in the field of medicine and beauty earlier. The earliest application of collagen in the field of medical aesthetics can be traced back to zyderm, which was approved by FDA in 1981. At that time, botulinum toxin and hyaluronic acid products had not been listed. It accounted for 90% of the soft tissue filler Market in the United States and 10.7% of all minimally invasive products; Since then, the reduction of market scale is mainly due to the occupation of hyaluronic acid market, the pursuit of long-term products by beauty seekers and the safety problems of early collagen products.

Collagen filler: high growth under precise application around the orbit, with an estimated scale of nearly 1 billion. At present, there are about 40 types of hyaluronic acid products approved by nmpa for listing in China. The market competition is fierce. Collagen is based on the characteristics of milky white, not easy to move and not water absorption and expansion, which makes up for the defects of hyaluronic acid. In recent years, its precise application around the orbit has made it a new force. The export volume of Shuangmei in 20 years is 166000 ml. it is estimated that 90% (150000 ml) will be sold in mainland China (the sales volume of Fuman is small). Taking the terminal price of 7000 yuan / ml as the market price (considering the discount sales and relatively low price of American plastic products, and the scale of American plastic products is small), it is estimated that the market scale is about 1 billion yuan, It accounts for less than 3.33% of the market scale of more than 30 billion yuan in injection grade medicine and the United States in China; At present, only three enterprises in China have obtained five approvals for collagen skin fillers, namely furoumei, fulimei (cross-linked), Fuliyuan (cross-linked with lidocaine) under Shuangmei, Fuman under Changchun Botai, and “recombinant type III humanized collagen lyophilized fiber” newly approved by Jinbo biology in June this year (in addition, new products are in the process), The market competition pattern is better than that of hyaluronic acid injection.

The industrialized preparation of collagen is on the way, and the price is higher than that of hyaluronic acid. Due to the difficulty of industrialized preparation of collagen, its price is higher than that of hyaluronic acid (the cost of injection grade is about 10000 yuan / kg). According to Shuangmei, the cost of its filler is about 70 yuan / ml. according to the concentration of 35mg / ml, only the cost of collagen is nearly 2 million yuan / kg; According to Jinbo, the price of recombinant humanized collagen is about 1000 yuan / g (calculated according to 90% gross profit margin).

With the capacity expansion and technological progress of collagen manufacturers, it is expected that the price of collagen will decline and promote the development of the industry.

Collagen dressing: outstanding repair function and wide demand for postoperative matching. Collagen has excellent repair performance. With the improvement of the frequency and frequency of light medical beauty such as photoelectric and microneedle, medical skin repair dressing meets the postoperative nursing needs of light medical beauty. In 2019, the consumption of patch medical skin dressing reached 340 million pieces, with sales of more than 5 billion yuan. Medical repair dressings need to apply for medical device approvals. As of June 30, 2020, there are 467 approvals for medical skin repair dressings in China, including 66 approvals containing hyaluronic acid and collagen components. In addition, the terminal price of collagen dressings is generally higher than that of hyaluronic acid dressings.

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