Farnesol in fruits can prevent and reverse Parkinson’s disease-related brain damage From Johns Hopkins medical school

The following is the Farnesol in fruits can prevent and reverse Parkinson’s disease-related brain damage From Johns Hopkins medical school recommended by recordtrend.com. And this article belongs to the classification: Life data.

Johns Hopkins medical researchers said that additional evidence showed that farnesol, a compound naturally found in herbs, berries and other fruits, could prevent and reverse brain damage associated with Parkinson’s disease in experimental mice. This compound, widely used in flavoring and perfume manufacturing, prevents the loss of dopamine neurons in the brain of mice by inactivating PARIS, a key protein involved in disease progression.

The loss of these neurons can affect movement and cognition, leading to the hallmark symptoms of Parkinson’s disease, such as tremor, muscle stiffness, confusion and dementia. The researchers said that the ability of farnesol to block Paris could guide the development of new Parkinson’s disease interventions specifically targeting this protein.

Ted Dawson, MD, director of John College, said: “our experiments show that farnesol can not only significantly prevent the loss of dopamine neurons in mice, but also reverse behavioral defects in mice, which shows that it is expected to become a potential drug treatment for the prevention of Parkinson’s disease.”.

The results of this new study were published in Science Translational Medicine on July 28, 2021. It introduces in detail how researchers determine the potential of farnesol by screening a large drug library to find drugs that inhibit Paris.

In the brains of patients with Parkinson’s disease, the accumulation of Paris slows down the production of the protective protein PGC-1alpha. This protein protects brain cells from the accumulation of reactive oxygen molecules in the brain. Without PGC-1alpha, dopamine neurons die, leading to cognitive and physical changes associated with Parkinson’s disease.

To investigate whether farnesol could protect the brain from Paris accumulation, the researchers fed mice a farnesol supplemented diet or a conventional mouse diet for one week. The researchers then managed the protein α- Synuclein is a preformed fibril, which is related to the effect of Parkinson’s disease on the brain.

The researchers found that mice fed a farnesol diet performed better in strength and coordination tests designed to detect the progression of symptoms of Parkinson’s disease. On average, these mice performed better than injection α- Synuclein but mice on a normal diet were 100% better.

When the researchers later studied the brain tissue of two groups of mice, they found that the number of healthy dopamine neurons in mice fed a farnesol rich diet was twice that of mice not fed a farnesol rich diet. Mice fed with farnesol also had about 55% more protective protein PGC-1alpha in the brain than untreated mice.

More reading from cnBeta: British Medical Research Council: the study found that wounds heal faster during the day. Cambridge University: the study found that working one day a week is the most conducive to health. ESI: in 2018, the University of science and technology of China ranked first in the ranking of universities in mainland China. C3S: a record of global temperature in May 2020. Bourne University: the study found that eating too salty will reduce immunity. Medicine: Internal Medicine: the study found Traffic accident mortality caused by drug addiction driving cbndata: why do we love “Wonder Woman” more? Georgetown University: China Kwai TSE graduates will be two times the number of STEM graduates in the United States in 2025. Washington State University: research shows that the horrific cigarette box helps to control tobacco. The National Academy of Sciences of the United States: the world’s 7 billion 600 million population accounts for only 0.01% of the earth’s biomass: 2019 young people reported that the LOL game player’s visual selective attention was more concentrated than the ordinary people’s United Nations AIDS program. Department of health: 2017, the world has been treated with AIDS over 50%HBR: the 34% of the US working population in freelance occupation has shown that brother Viagra can help prevent malaria transmission.

If you want to get the full report, you can contact us by leaving us the comment. If you think the information here might be helpful to others, please actively share it. If you want others to see your attitude towards this report, please actively comment and discuss it. Please stay tuned to us, we will keep updating as much as possible to record future development trends.

RecordTrend.com is a website that focuses on future technologies, markets and user trends. We are responsible for collecting the latest research data, authority data, industry research and analysis reports. We are committed to becoming a data and report sharing platform for professionals and decision makers. We look forward to working with you to record the development trends of today’s economy, technology, industrial chain and business model.Welcome to follow, comment and bookmark us, and hope to share the future with you, and look forward to your success with our help.