Significant progress! Eating a calorie restricted diet at the right time is expected to greatly prolong life From Science
The following is the Significant progress! Eating a calorie restricted diet at the right time is expected to greatly prolong life From Science recommended by recordtrend.com. And this article belongs to the classification: Life data.
One of the secrets of longevity is simply to eat less, but it’s not easy for people to do so. Studies on various animals have shown that calorie restriction can lead to a longer and healthier life.
Now, in a new study, Howard Hughes Institute of medicine researcher Joseph Takahashi and his colleagues point out that the body’s circadian rhythm (i.e. biological clock) plays a big role in this longevity effect. They reported that eating only at the most active time of the day significantly prolonged the life span of mice on a reduced calorie diet. The relevant research results were published online in the journal Science on May 5, 2022. The title of the paper is “circular alignment of early only quantitative restriction promotion longevity in male C57BL / 6J mice”.
In the four-year study of hundreds of mice by Takahashi and his team, a calorie restricted diet alone increased the lifespan of mice by 10%. But feeding mice a calorie restricted diet only at night – when they are most active – can prolong their life by 35%. This combination – a calorie restricted diet plus a nighttime eating schedule – increased the median lifespan of these mice, usually two years, by nine months. For humans, a similar time plan is to limit diet to daytime.
Takahashi said the study could help unravel the controversy surrounding eating plans that emphasize eating only at specific times of the day. As stated in a recent study published in the journal NEJM, such dietary plans may not speed up human weight loss, but they may bring health benefits and prolong life (NEJM, 2022, DOI: 10.1056 / nejmoa2114833).
Sai Krupa DAS, a nutritionist at the USDA human nutrition research center who was not involved in the new study, said the Takahashi team’s findings highlighted the key role of metabolism in aging. “This is a very promising and landmark study,” she said
Spring of youth
Decades of research have found that calorie restriction can prolong the life span of everything from nematodes and fruit flies to mice, rats and primates. These experiments reported weight loss, improved glucose regulation, decreased blood pressure and reduced inflammation.
But it has been difficult to systematically study calorie restriction in people, DAS said, because people can’t live in the laboratory and eat quantitative food all their life. She was a member of the first research team to conduct a controlled study on human calorie restriction, called calerie (comprehensive assessment of long-term effects of reducing intake of energy). Das said that in the calerie study, even a modest reduction in calories had “significant benefits” in reducing signs of aging.
Scientists are just beginning to understand how calorie restriction slows aging at the cellular and genetic levels. As animals age, genes associated with inflammation tend to become more active, while genes that help regulate metabolism become less active. The new study by Takahashi’s team found that calorie restriction, especially when mice are active at night, helps offset these genetic changes in mice as they age.
Time problem
In recent years, many popular dietary programs have sprung up, focusing on so-called intermittent fasting, such as fasting every other day or eating only for six to eight hours a day. To reveal the effects of calories, fasting and circadian rhythms on longevity, Takahashi’s team conducted an extensive four-year experiment. The team raised hundreds of mice with automatic feeders to control the time and number of meals each mouse ate throughout its life cycle.
Some mice can eat as much as they want, while others are limited in calories by 30% to 40%. Those fed a calorie restricted diet ate at different times. Takahashi’s team found that mice fed a low calorie diet for two or 12 hours at night had the longest life span.
Picture from NEJM, 2022, DOI: 10.1056/nejmoa2114833.
These results suggest that a time limited diet has a positive effect on the body, even if it does not promote weight loss. Takahashi pointed out that his study also did not find differences in body weight between mice at different eating times. “However, we found significant differences in life expectancy.”.
Rafael de Cabo, a gerontology researcher at the National Institute on aging, said the paper “elegantly proves that even if you eat a calorie restricted diet, you can’t get the full benefits of calorie restriction without [eating at the right time]”.
Takahashi hopes to understand how calorie restriction affects the body’s internal clock as we age, which will help scientists find new ways to prolong human healthy life. This may be achieved by eating a calorie restricted diet or by drugs that mimic the effects of such a diet.
Meanwhile, Takahashi is learning a lesson from his mice – he limits his diet to 12 hours. However, he said, “if we find a drug that can enhance the action of the biological clock, we can test it in the laboratory to see if it can prolong life.”
reference material:
1. Victoria Acosta-Rodríguez et al. Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice. Science, 2022, doi:10.1126/science.abk0297.
2. Cutting Calories and Eating at the Right Time of Day Leads to Longer Life in Mice
https://www.hhmi.org/news/cutting-calories-and-eating-right-time-day-leads-longer-life-mice
From: biological Valley more reading: Science heavyweight: eating “eight full” can delay aging, revealing key factors. Research shows that short-term fasting can significantly improve physical function and be vegetarian and healthier? NO！ The latest research shows that, Eating meat can help prolong life. University of Bonn: research has found that eating too salty can reduce the nostalgia of the immune nervous system: why do we always fall in love with the old song Artprice: statista, the top 20 female artists in the global art market in 2018: survey on German sexual life satisfaction Euromonitor information Consulting: the meaning of probability that post-80s and millennials think hip wrapped underwear is cooler than Thongs: random world and the law of large numbers Philosophical significance of the probability that the global next generation sequencing (NGS) market will reach US $30 billion in 2022 | all science is mathematics and all judgments are statistics nature: the culprit of weight gain after quitting smoking may lie in the new discovery of intestinal microorganisms! Lack of sleep, belly fat, worry free future: 2022 survey on the current situation of overtime in the workplace ESI: in 2018, the University of science and technology of China ranked first
If you want to get the full report, you can contact us by leaving us the comment. If you think the information here might be helpful to others, please actively share it. If you want others to see your attitude towards this report, please actively comment and discuss it. Please stay tuned to us, we will keep updating as much as possible to record future development trends.
RecordTrend.com is a website that focuses on future technologies, markets and user trends. We are responsible for collecting the latest research data, authority data, industry research and analysis reports. We are committed to becoming a data and report sharing platform for professionals and decision makers. We look forward to working with you to record the development trends of today’s economy, technology, industrial chain and business model.Welcome to follow, comment and bookmark us, and hope to share the future with you, and look forward to your success with our help.
