The negative impact of obesity on health lies not in excess fat but in loss of function From Cell

The following is the The negative impact of obesity on health lies not in excess fat but in loss of function From Cell recommended by recordtrend.com. And this article belongs to the classification: Life data.

As everyone knows, obesity can lead to heart and metabolic diseases such as hypertension and diabetes, but it is a simplification to attribute these diseases to excessive fat. At the basic level, fat acts as a container for storing energy, but careful observation shows that it plays an important role in important body processes such as immune response, regulation of insulin sensitivity and maintenance of body temperature.

In a review type article entitled “adipose tissue plasticity in health and disease” published in the cell Journal on February 3, 2022, researchers believe that the negative impact of obesity on health is not only due to excessive fat, but also due to its reduced response to change, or in other words, its decreased plasticity.

Adipose tissue plasticity, picture from cell, 2022, DOI: 10.1016/j.cell 2021.12.016。

The composition and function of adipose tissue will change with weight fluctuation and aging. The body loses its ability to respond to fat and plasticity. In the current model of this phenomenon, the rapid growth of adipose tissue exceeds its blood supply, depriving adipocytes of oxygen and leading to the accumulation of adipocytes that no longer divide. This leads to insulin resistance, inflammation and cell death, accompanied by uncontrolled lipid overflow in these cells.

“The central role of adipose tissue dysfunction in disease and the incredible plasticity of adipose tissue support the prospect of regulating adipose tissue phenotype for therapeutic purposes. There are still many problems and opportunities to be found in the future, which will generate new insights into adipose tissue biology and hopefully improve the treatment of human diseases,” the authors said

reference material:

Alexander Sakers et al. Adipose-tissue plasticity in health and disease. Cell, 2022, doi:10.1016/j.cell.2021.12.016.

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