Research shows that reducing calorie intake and eating at the right time of day can prolong life From HHMI

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In a four-year study of hundreds of mice by Takahashi’s team, a calorie reduced diet alone increased the lifespan of animals by 10%. But feeding the mice only at night, when they were most active, could prolong their life by 35%. This combination – a reduced calorie diet combined with a nighttime eating program – increased the typical two-year median life span of an animal by nine months. For humans, a considerable plan is to limit diet to daytime.

Takahashi, a molecular biologist at the University of Texas Southwestern Medical Center, said the study could help unravel the debate over a diet that emphasizes eating only at certain times of the day. As a recent research report in the New England Journal of medicine States, such programs may not speed up human weight loss, but they may promote health benefits and prolong life.

Takahashi’s team’s findings emphasize the key role of metabolism in aging. Jean Mayer, nutritionist Sai Krupa Das of the human nutrition research center of the U.S. Department of agriculture, said: “this is a very promising and landmark study.” It is reported that he did not participate in this work.

Fountain of youth

Decades of research have found that calorie restriction prolongs the lifespan of everything from worms and flies to mice, rats and primates. These experiments reported weight loss, improved glucose regulation, decreased blood pressure, and decreased inflammation.

Das said, however, it has been very difficult to systematically study calorie restriction in people, because it is impossible for people to live in the laboratory and eat quantitative food all their lives. She is a member of the research team that conducted the first controlled study of calorie restriction in humans – the comprehensive assessment of the long-term effects of reducing energy intake (calerie). Das pointed out that in this study, even modest calorie reduction showed significant benefits in reducing signs of aging.

Scientists are just beginning to understand how calorie restriction slows aging at the cellular and genetic levels. As animals age, genes related to inflammation tend to become more active, while genes that help regulate metabolism become less active. Takahashi’s new study found that calorie restriction, especially during nocturnal activity in mice, helps offset these genetic changes in aging mice.

Time issues

In recent years, many popular dietary programs have sprung up, focusing on so-called intermittent fasting, such as fasting every other day or eating only for six to eight hours a day. To reveal the effects of calories, fasting and daily or circadian rhythms on longevity, Takahashi’s team conducted an extensive four-year experiment. The team fed hundreds of mice with automatic feeders to control the feeding time and quantity of each mouse throughout its life cycle.

Some mice could eat as much as they wanted, while others were restricted to 30 to 40 percent of their calories. Those on a calorie restricted diet ate at different times. The team found that mice fed a low calorie diet at night and within two or 12 hours lived the longest.

These results suggest that a time limited diet has a positive effect on the body, even though it does not promote weight loss as the study in the New England Journal of medicine did. Takahashi pointed out that his study also did not find any difference in the weight of mice with different eating times – “however, we found a profound difference in life span.”

Rafael de Cabo, a gerontology researcher at the National Institute on aging in Baltimore, pointed out that this study “shows very carefully that even if you are restricting calories, you can’t get the full benefits of restricting calories without (eating at the right time).”

Takahashi hopes that learning how calorie restriction affects the body’s internal clock as we grow older will help scientists find new ways to extend the healthy life span of human beings. This may be achieved through calorie limiting diets or drugs that mimic the effects of these diets.

Meanwhile, Takahashi is learning a lesson from his mice – he limits his diet to 12 hours. But he said – “if we find a drug that can improve your clock, we can test it in the laboratory to see if it will prolong your life.” More reading: University of Southern California: research shows that PM2.5 increases the risk of dementia in elderly women university of Pennsylvania: research shows that the main culprit of male aging is the lack of estrogen secretion. Why do you want to eat more after eating? Tour de France: data show that cycling is good for your health and can prolong your life by six years. Lancet: Research on more than one million people reveals that Omicron’s risk of hospitalization is reduced by 59%, except for this age group… New research shows that: after 4 hours of drama, the risk of thrombosis is increased by 35%! The time of having sex for the first time and becoming a parent have long been engraved in the DNA. Research on data from thousands of people shows that whether men are “playful” may depend on testosterone secretion. Research has found that eating a good breakfast can prevent obesity Hyperglycemia Anglia Ruskin University, UK: the study found that women who drink twoorthree cups of coffee a day have less body fat. International Journal of cancer: the study found that eating cruciferous vegetables reduces the risk of breast cancer by 11%. University of Basel, Switzerland: the study found that the fitness effect of motorcycles is as good as that of ordinary bicycles. The study shows that human sleep time is far lower than that of other primates. The great victory of tobacco control: why do people like the decline in the number of cancer in the United States To “forever 18”?

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